Pathways to a cancer-free future: a protocol for modelled evaluations to minimise the future burden of colorectal cancer in Australia

Introduction With almost 50% of cases preventable and the Australian National Bowel Cancer Screening Program in place, colorectal cancer (CRC) is a prime candidate for investment to reduce the cancer burden.The challenge is determining effective ways to reduce morbidity and mortality and their implementation through policy and practice.Pathways-Bow

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Prospects of the Use of Cell Therapy to Induce Immune Tolerance

Conditions in which abnormal or excessive immune responses exist, such as autoimmune diseases (ADs), graft-versus-host disease, transplant rejection, and hypersensitivity reactions, are serious hazards to human health and well-being.The traditional immunosuppressive drugs used to treat these conditions can lead to decreased immune function, a highe

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Inhibition of malate dehydrogenase via nanoselenium coupling with nanocellulose composite in MCF-7 breast carcinoma cells

Abstract Background Cancer, a leading cause of mortality worldwide, continues to pose significant challenges in treatment and management.Conventional therapies often face limitations, including lack of selectivity, adverse effects, and the development of resistance mechanisms.Methods Therefore, this study aims to investigate nanocellulose, nanosele

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Macrophages Infected by a Pathogen and a Non-pathogen Spotted Fever Group Rickettsia Reveal Differential Reprogramming Signatures Early in Infection

Despite their high degree of genomic similarity, different spotted fever group (SFG) Rickettsia are often associated with very different clinical presentations.For example, Rickettsia conorii causes Mediterranean spotted fever, a life-threatening disease for humans, whereas Rickettsia montanensis is associated with limited or no pathogenicity to hu

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